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Patients with severe renal impairmentincluding those receiving dialysissee CLINICAL PHARMACOLOGYpatients with active liver diseaseincluding those with primary biliary cirrhosis and unexplained persistent liver function abnormalitiessee WARNINGS AND PRECAUTIONSpatients with preexisting gallbladder diseasesee WARNINGS AND PRECAUTIONSnursing motherssee Use In Specific Populationspatients with known hypersensitivity to fenofibrate or fenofibric acidsee WARNINGS AND PRECAUTIONS
Baseline and regular periodic monitoring of liver functionincluding serum ALTSGPTshould be performed for the duration of therapy with TRICORand therapy discontinued if enzyme levels persist above three times the normal limit.
Potentiation of coumarin-type anticoagulant effects has been observed with prolongation of the PT/INR.
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treatment with tricor should be initiated at a dose of 54 mg per day in patients having mild to moderately impaired renal function, and increased only after evaluation of the effects on renal function and lipid levels at this dose.